ABSTRACT
Background: The Computed Tomography Scan (CT scan) was widely used for SARS-CoV-2 pneumonia evaluation and its correlation with clinical and laboratory findings is useful in clinical management. Aims and objectives: This study examines the clinical and functional features of COVID-19 pneumonia in relation with the extent of ground glass (GGO) and consolidation areas defined by volumetric investigations on CT scan. Method(s): Sixty-one patients attending the emergency department were enrolled. A semi-automatic segmentation software was used to extract volumetric data that has been compared with clinical and laboratory findings. Result(s): The decrease of aerated lung volume with the increase of GGO and consolidation areas were strongly related with a decrease of P/F ratio (p<0.0001, p<0.0001 and p=0.0002 respectively). An inverse correlation was observed between GGO and consolidation areas with P/F (R= -0.62, p<0.0001 and R= -0.4 and p=0.003, respectively). No significant correlation was observed between consolidation versus ground glass opacities ratio (C/GGO) and P/F. The increase of GGO and consolidation corresponded to an increase in CRP (R=-0.68, p<0.0001) and LDH (R=-0.55, p<0.0001) and a decrease in both the absolute number and the percentage of lymphocytes (respectively: R= 0.48, p<0.0001 and R= 0.54, p<0.0001) with a similar increase of neutrophils (respectively: R= -0.33, p=0.01 and R= -0.54, p<0.0001). These parameters had a stronger correlation with GGO than with consolidation areas. Conclusion(s): The extension and the characteristics in terms of GGO and consolidation of the lung lesions have a significant correlation with P/F reduction, CRP and LDH increase and lymphocytes decrease.
ABSTRACT
Covid-19's pandemic expansion to more than 100 countries around the world has prompted several governments to enact restrictive social mobility measures, known as 'social isolation'. Associated with this fact, a disease with the possibility of causing serious complications generates fear, anxiety and stress. This new scenario, as a side effect, could cause the development or worsening of several psychiatric syndromes. The entire population is touched by the context of a pandemic, but the frontline professionals is a group at risk for the development of psychopathologies associated with exhaustion, frustrations and feelings of helplessness in the face of the increased demands imposed on the health area. Although the relationship between the pandemic and the repercussions for mental health proposed in this work is an extremely relevant topic, it is known that further studies are still needed. This information can be corroborated by the fact that it is still a new disease, which needs further studies in several aspects. Due to this lack, the present study searched for relevant information in several digital libraries, in order to integrate data on the theme addressed.